Yes, it is possible to run DotNetNuke with Oracle. To do so, however, requires that you replace the DotNetNuke SqlDataProvider with an Oracle dataprovider. You will need to do this for the basic DotNetNuke framework AND for every module that you install that has a dataprovider. Modules that don't use the dataprovider model may not be usable.
If you want to look into this, the only Oracle dataprovider that I know of is available for purchase here:
http://www.acuitisolutions.com/Solu...tiDP.aspx. I strongly recommend that you contact the vendor of this product for more details. I'd like to be assured that this is going to be maintained and upgraded, and I would like to know which module are supported.
I also recommend that you read this:
http://weblogs.asp.net/christoc/arc...acle.aspx. Chris Hammond is a respected member of the DotNetNuke community.